Dr. Robert Lustig: How Sugar & Processed Foods Impact Your Health [0e6030]

Post Time: 2025-09-01

Blood Sugar Levels After Eating: All the Basics

Understanding blood sugar levels after eating, also known as postprandial glucose levels, is crucial for maintaining overall health and preventing diabetes. The food we eat directly impacts our blood glucose levels, and knowing how this process works can empower us to make healthier choices. After a meal, especially one rich in carbohydrates, our bodies break down these carbs into glucose, which is then absorbed into the bloodstream. This increase in blood sugar triggers the release of insulin from the pancreas, a hormone that helps transport glucose from the blood into our cells to be used for energy. This dynamic interaction between food, glucose, and insulin is what determines our postprandial glucose response.

It's essential to recognize that not all foods have the same impact on blood sugar levels. Foods with a high glycemic index (GI), like white bread, sugary drinks, and processed snacks, tend to cause a rapid and significant spike in blood sugar. On the other hand, foods with a low GI, such as whole grains, most fruits, and non-starchy vegetables, lead to a more gradual and manageable rise. Managing these levels, especially post-meal spikes, is crucial for maintaining energy levels and reducing long-term health risks. This isn’t just a concern for individuals with diabetes; anyone can benefit from learning more about this process to make healthier choices. Understanding the connection between what we eat and how our bodies process glucose is fundamental for long-term wellness.


Understanding Postprandial Glucose: What Happens After a Meal?

Postprandial glucose, or blood glucose after eating, typically peaks about one to two hours after a meal, before gradually returning to baseline levels. This normal fluctuation is a sign of a healthy metabolic response to food. However, for individuals with conditions like diabetes or insulin resistance, this rise can be more dramatic and prolonged, potentially leading to hyperglycemia (high blood sugar). There are several critical stages and biological responses happening here. Firstly, the digestion process kicks off the conversion of complex carbohydrates into simple sugars like glucose. Once these glucose molecules enter the bloodstream, the pancreas immediately registers the increase and responds by secreting insulin. Insulin acts like a key, unlocking the cells to let glucose enter and provide energy. This process is vital for ensuring the body has access to the necessary energy while maintaining optimal glucose levels in the blood.

However, factors like meal composition play a huge role. If a meal is largely composed of simple carbohydrates (sugary snacks, white bread, etc), the glucose influx is fast, causing a quick and high spike in postprandial glucose levels. This then requires the pancreas to produce a large quantity of insulin. In some cases, this intense insulin response can lead to a ‘crash’ afterward, as the body becomes too effective in moving glucose out of the blood leading to hypoglycemia (low blood sugar). In contrast, balanced meals that include complex carbohydrates, proteins, and healthy fats result in a more stable and sustained release of glucose into the blood. This gradual rise allows the insulin to manage glucose absorption more efficiently without drastic blood sugar swings. Therefore, monitoring and understanding the body’s response to food can aid in making informed decisions about what we eat.

Time After Meal Typical Blood Glucose Response Key Bodily Response
0-30 Minutes Initial rise, varies with meal type Digestion begins, glucose enters bloodstream
30-60 Minutes Rapid increase, insulin release begins Pancreas releases insulin to manage rise
60-120 Minutes Peak blood sugar levels Glucose transported into cells
2-4 Hours Return to baseline level Insulin lowers blood glucose, normal levels

What are Normal Postprandial Blood Sugar Levels?

Understanding what constitutes a normal postprandial blood sugar level is crucial. Typically, for a healthy individual, a blood glucose level of less than 140 mg/dL (7.8 mmol/L) two hours after the start of a meal is considered normal. This number can fluctuate somewhat based on individual metabolic rates and the composition of the meal. In contrast, if the reading goes higher than this consistently, then further investigation is usually required. The American Diabetes Association provides guidelines that further help with classifying readings, which are as follows:

  • Normal: Less than 140 mg/dL (7.8 mmol/L) two hours after the start of a meal.
  • Pre-diabetes: Between 140 and 199 mg/dL (7.8 - 11 mmol/L) two hours after the start of a meal, which indicates impaired glucose tolerance and a higher risk of progressing to Type 2 diabetes.
  • Diabetes: 200 mg/dL (11.1 mmol/L) or higher, and this needs immediate medical intervention.

These are guidelines. For individuals with diabetes or those being monitored for pre-diabetes, understanding their specific targets is essential, often guided by healthcare providers. For such individuals, readings are typically taken both before meals (fasting glucose levels) and after meals. Consistent elevated readings require adjustments in lifestyle, medication, or both. It is important to have the postprandial blood sugar levels in the healthy range so the body's metabolic function remains efficient and prevent any organ damage caused by high glucose levels. Regular monitoring of post-meal glucose levels, especially after consuming meals high in simple carbohydrates, is a useful preventative measure for understanding your own individual reactions and maintaining your health effectively. If one is consistently seeing values that are not in the healthy range, it would be very prudent to get professional advice.


Factors Influencing Postprandial Glucose Levels

Several factors can influence blood sugar levels after eating, and it's beneficial to be aware of them to manage our health proactively. First and foremost, the composition of the meal is critical. High-carbohydrate meals, particularly those rich in simple sugars like white rice, pastries, and sweetened beverages, cause a much more rapid and substantial increase in blood sugar compared to meals with complex carbohydrates, proteins, and healthy fats. The Glycemic Index (GI) of a food helps indicate how quickly a food will raise blood sugar. Foods with a high GI have a rapid, high impact on blood glucose whereas foods with a low GI have a gradual, lower impact on the blood glucose levels. Understanding and choosing low GI food alternatives is very helpful in managing glucose response. Secondly, the size of the meal matters. Larger meals mean more carbohydrates to process, leading to a greater demand for insulin and potentially a higher spike in glucose. Portion control is key, as reducing overall carb intake during any sitting can have a large effect on lowering postprandial glucose.

Third, individual metabolic factors like insulin sensitivity and overall health status can dramatically change glucose response. For individuals with conditions like insulin resistance, pre-diabetes, or diabetes, postprandial glucose levels can show exaggerated responses that require ongoing monitoring and active management. Similarly, other lifestyle factors come into play, like physical activity. Engaging in physical exercise, especially soon after eating, can greatly assist in using the glucose from food and prevent high glucose readings from taking place. Timing also plays a vital role as the closer a physical activity session is to a mealtime, the higher the impact on the immediate reduction of postprandial glucose. Lastly, stress, illnesses, or medications can also influence blood sugar levels after eating and might need extra management strategies.

Factor Effect on Postprandial Glucose
Meal Composition High simple carb meals increase it; Complex carbs reduce it
Meal Size Larger meals often cause a greater spike
Glycemic Index High GI foods lead to rapid increase; Low GI foods lead to gradual rise
Insulin Sensitivity Resistance leads to higher levels; Better sensitivity means lower levels
Physical Activity Exercise helps lower it, especially post-meal
Other Health Conditions Illness and stress can lead to higher readings

Practical Tips for Managing Blood Sugar After Meals

Effectively managing blood sugar after meals involves making strategic dietary and lifestyle adjustments. First and foremost, focus on incorporating balanced meals that include complex carbohydrates, lean proteins, and healthy fats. Choosing whole grains, legumes, and non-starchy vegetables over simple refined carbs can prevent rapid rises in postprandial glucose. For example, opting for brown rice instead of white rice, or sweet potatoes over regular potatoes are great choices that result in less glucose spiking. Moreover, be mindful of portion sizes. Smaller meals distributed more frequently throughout the day can help stabilize blood sugar levels better than larger, less frequent ones.

Another important strategy is to understand and incorporate the Glycemic Index (GI) concept, by selecting food that have a low GI as these cause less fluctuations in blood sugar levels. Moreover, increase your intake of fiber from whole grains and vegetables, as fiber significantly slows down the rate at which glucose enters the bloodstream. This stabilization prevents large, immediate spikes and provides better sustained energy, making it easier to avoid the ‘crash’ often felt after eating simple carb foods. Secondly, try to incorporate physical activity as soon after meals as possible. Going for a short walk after meals, or doing any kind of movement will help your body use the glucose and help to bring down postprandial glucose. Finally, it is useful to track your postprandial glucose levels at different time intervals (for example after 1 hour, 2 hours and so on after eating) and analyze the glucose curves. You can then correlate them to the meal choices. This personalized approach will help you to become better informed and hence make better meal choices.

Strategy How It Helps Manage Blood Sugar
Balanced Meals Combines protein, carbs and fat to prevent sharp spikes
Portion Control Prevents excessive carb intake at a time that reduces demand on insulin
Choose Low GI Foods Slows down glucose absorption to help stabilize glucose levels
Increase Fiber Aids in slower digestion and reduces postprandial glucose spikes
Post-Meal Physical Activity Increases glucose uptake into cells and decreases the blood glucose levels and helps the energy distribution
Monitor Postprandial Glucose By monitoring patterns, one can create more personalized nutritional strategies that work well
In this episode, my guest is does drinking cause high blood sugar Dr. Robert Lustig, M.D., neuroendocrinologist, professor of pediatrics at the University of California, San Francisco (UCSF), and a bestselling author on nutrition and metabolic health. We address the “calories in- calories out” (CICO) model of metabolism and weight regulation and how specific macronutrients (protein, fat, carbohydrates), fiber and sugar can modify the CICO equation. We cover how different types of sugars, specifically fructose, sugars found in liquid form, taste intensity, and other factors impact insulin levels, liver, kidney, what's the normal blood sugar reading and metabolic health. We also explore how fructose in non-fruit sources can be addictive (acting similarly to drugs of abuse) and how sugar alters brain circuits related to food cravings and satisfaction. We discuss the role of sugar in childhood and adult obesity, gut health and disease and mental health. We also discuss how the food industry uses refined sugars to create pseudo foods and what these do to the brain and body. This episode is replete with actionable information about sugar and metabolism, weight control, brain health and body composition. It ought to be of interest to anyone seeking to understand how specific food choices impact the immediate and long-term health of the brain and body. For the show notes, including referenced articles and additional resources, please visit Thank you to our sponsors AG1: Eight Sleep: Levels: AeroPress: LMNT: Momentous: Huberman Lab Social & Website Instagram: Twitter: Facebook: TikTok: LinkedIn: Website: Newsletter: Dr. Robert Lustig Website: Books: Publications: Blog: UCSF academic profile: Metabolical (book): SugarScience: X: Facebook: LinkedIn: Instagram: Threads: Timestamps 00:00:00 Dr. Robert Lustig 00:02:02 Sponsors: Eight Sleep, Levels & AeroPress 00:06:41 Calories, Fiber 00:12:15 Calories, Protein & Fat, Trans Fats 00:18:23 Carbohydrate Calories, Glucose vs. Fructose, Fruit, Processed Foods 00:26:43 Fructose, Mitochondria & Metabolic Health 00:31:54 Trans Fats; Food Industry & Language 00:35:33 Sponsor: AG1 00:37:04 Glucose, Insulin, does drinking cause high blood sugar Muscle 00:42:31 Insulin & Cell Growth vs. Burn; Oxygen & Cell Growth, Cancer 00:51:14 Glucose vs. Fructose, Uric Acid; “Leaky Gut” & Inflammation 01:00:51 Supporting the Gut Microbiome, Fasting 01:04:13 Highly Processed Foods, Sugars; “Price Elasticity” & Food Industry 01:10:28 Sponsor: LMNT 01:11:51 Processed Foods & Added Sugars 01:14:19 Sugars, High-Fructose Corn Syrup 01:18:16 Food Industry & Added Sugar, Personal Responsibility, Public Health 01:30:04 Obesity, Diabetes, “Hidden” Sugars 01:34:57 Diet, Insulin & Sugars 01:38:20 Tools: NOVA Food Classification; Perfact Recommendations 01:43:46 Meat & Metabolic Health, Eggs, Fish 01:46:44 Sources of Omega-3s; Vitamin C & Vitamin D 01:52:37 Tool: Reduce Inflammation; Sugars, Cortisol & Stress 01:59:12 Food Industry, Big Pharma & Government; Statins 02:06:55 Public Health Shifts, Rebellion, Sugar Tax, Hidden Sugars 02:12:58 Real Food Movement, Public School Lunches & Processed Foods 02:18:25 3 Fat Types & Metabolic Health; Sugar, Alcohol & Stress 02:26:40 Artificial & Non-Caloric Sweeteners, Insulin & Weight Gain 02:34:32 Re-Engineering Ultra-Processed Food 02:38:45 Sugar & Addiction, Caffeine 02:45:18 GLP-1, Semaglutide (Ozempic, Wegovy, Tirzepatide), Risks; Big Pharma 02:57:39 Obesity & Sugar Addiction; Brain Re-Mapping, Insulin & Leptin Resistance 03:03:31 Fructose & Addiction, Personal Responsibility & Tobacco 03:07:27 Food Choices: Fruit, Rice, Tomato Sauce, Bread, Meats, Fermented Foods 03:12:54 Intermittent Fasting, Diet Soda, Food Combinations, Fiber, Food Labels 03:19:14 Improving Health, Advocacy, School Lunches, Hidden Sugars 03:26:55 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter #HubermanLab #Science #Nutrition Title Card Photo Credit: Mike Blabac - Disclaimer:
Dr. Robert Lustig: How Sugar & Processed Foods Impact Your Health
Dr. Robert Lustig: How Sugar & Processed Foods Impact Your Health [0e6030]