Exciting Developments In The Treatment Of Peripheral Neuropathy | Dr. Fernyhough & Dr. Calcutt [c6f411]

Post Time: 2025-09-01

What is Impaired Fasting Glucose and What Does It Mean For You?

Have you ever heard of impaired fasting glucose (IFG) and wondered what it means? Understanding IFG is crucial for proactively managing your health. In this article, we'll break down what IFG is, its causes, associated risks, and, most importantly, what you can do about it.

What is Impaired Fasting Glucose (IFG)?

Impaired fasting glucose (IFG), also known as prediabetes diagnosed specifically from a fasting blood sugar test, occurs when your blood glucose level is higher than normal after an overnight fast, but not high enough to be classified as diabetes. A fasting blood glucose level between 100 mg/dL (5.6 mmol/L) and 125 mg/dL (6.9 mmol/L) typically indicates IFG.

Think of it as a warning sign – a signal from your body that your glucose metabolism isn't working quite as it should. This doesn't automatically mean you'll develop type 2 diabetes, but it significantly increases your risk.

Causes and Risk Factors for Impaired Fasting Glucose

Several factors can contribute to the development of impaired fasting glucose. Understanding these can help you assess your personal risk.

  • Insulin Resistance: This is a key driver. Insulin is a hormone that helps glucose enter your cells for energy. When your cells become resistant to insulin, glucose builds up in your bloodstream, leading to higher fasting glucose levels.
  • Genetics: A family history of diabetes greatly increases your risk of developing IFG. Genes can influence how your body produces and uses insulin.
  • Obesity: Excess weight, particularly around the abdomen, is strongly linked to insulin resistance and, therefore, IFG.
  • Sedentary Lifestyle: Lack of physical activity reduces insulin sensitivity and can contribute to weight gain, both of which increase your risk.
  • Age: The risk of developing IFG increases with age, particularly after age 45.
  • Certain Medical Conditions: Polycystic ovary syndrome (PCOS) and certain cardiovascular conditions are associated with an increased risk of IFG.
  • Medications: Some medications, such as corticosteroids, can raise blood glucose levels.
  • Poor Diet: A diet high in processed foods, sugary drinks, and saturated fats can contribute to insulin resistance and weight gain.

Symptoms of Impaired Fasting Glucose

One of the trickiest aspects of impaired fasting glucose is that it often presents with no noticeable symptoms. This is why regular screening, particularly for those with risk factors, is so important.

However, some individuals may experience subtle signs like:

  • Increased thirst
  • Frequent urination
  • Fatigue
  • Blurred vision

These symptoms are more commonly associated with higher blood sugar levels, such as those seen in diabetes, but can occasionally occur in IFG. Therefore, relying solely on symptoms is not a reliable way to detect IFG. Regular blood tests are essential.

Why is Impaired Fasting Glucose a Concern?

The primary concern with impaired fasting glucose is its strong association with an increased risk of developing type 2 diabetes. Studies show that people with IFG are significantly more likely to progress to diabetes compared to those with normal fasting glucose levels.

Beyond diabetes, IFG is also linked to other health problems, including:

  • Cardiovascular Disease: IFG increases the risk of heart disease, stroke, and other cardiovascular complications.
  • Metabolic Syndrome: IFG is often a component of metabolic syndrome, a cluster of conditions that increase the risk of heart disease, stroke, and diabetes. These conditions include high blood pressure, high cholesterol, and excess abdominal fat.
  • Kidney Disease: High blood sugar levels can damage the kidneys over time, increasing the risk of kidney disease.
  • Nerve Damage (Neuropathy): Elevated blood sugar can damage nerves, leading to numbness, tingling, and pain, particularly in the hands and feet.

Diagnosis of Impaired Fasting Glucose

Diagnosis of impaired fasting glucose is straightforward and involves a simple blood test. Here's what to expect:

  1. Fasting Blood Glucose Test: You'll need to fast (no food or drinks other than water) for at least 8 hours before the test.
  2. Blood Sample Collection: A blood sample will be taken from a vein in your arm.
  3. Glucose Measurement: The blood sample is analyzed to measure your fasting blood glucose level.
  4. Interpretation of Results:

    • Normal: Less than 100 mg/dL (5.6 mmol/L)
    • Impaired Fasting Glucose (IFG): 100 mg/dL to 125 mg/dL (5.6 mmol/L to 6.9 mmol/L)
    • Diabetes: 126 mg/dL (7.0 mmol/L) or higher (on two separate tests)

It's crucial to discuss your results with your doctor, who can provide personalized recommendations based on your specific situation. Other tests, like an A1C test or an oral glucose tolerance test (OGTT), might also be recommended for a more complete assessment.

What Can You Do About Impaired Fasting Glucose?

The good news is that impaired fasting glucose is often reversible with lifestyle changes. Here are effective strategies you can implement:

  • Dietary Modifications:

    • Focus on Whole Foods: Emphasize fruits, vegetables, whole grains, and lean proteins.
    • Limit Processed Foods: Reduce your intake of processed foods, sugary drinks, and unhealthy fats.
    • Control Portion Sizes: Be mindful of portion sizes to avoid overeating.
    • Follow a Diabetes-Friendly Eating Plan: Consider a Mediterranean diet or a diet recommended by a registered dietitian.
  • Regular Physical Activity:

    • Aim for at least 150 minutes of moderate-intensity aerobic exercise per week: This could include brisk walking, cycling, or swimming.
    • Incorporate strength training: Strength training helps build muscle mass, which improves insulin sensitivity.
    • Break up sedentary time: Stand up and move around every 30 minutes to combat the negative effects of prolonged sitting.
  • Weight Management:

    • Losing even a small amount of weight (5-7% of your body weight) can significantly improve blood glucose levels:
    • Combine diet and exercise for effective weight loss.
    • Consult with a healthcare professional or registered dietitian for personalized weight management guidance.
  • Stress Management:

    • Chronic stress can raise blood sugar levels: Find healthy ways to manage stress, such as meditation, yoga, or spending time in nature.
    • Ensure you get adequate sleep, as sleep deprivation can also impact blood sugar control.
  • Medication (if recommended by your doctor):

    • In some cases, your doctor may recommend medication, such as metformin, to help lower blood glucose levels:
    • Medication is typically considered in conjunction with lifestyle changes.
    • Discuss the potential benefits and risks of medication with your doctor.

Monitoring and Follow-Up

If you've been diagnosed with impaired fasting glucose, regular monitoring of your blood glucose levels is essential. Your doctor will recommend a schedule for follow-up testing, which may include:

  • Fasting blood glucose tests
  • A1C tests
  • Oral glucose tolerance tests (OGTT)

These tests help track your progress and identify any potential progression to diabetes. It's also crucial to maintain regular appointments with your healthcare provider to discuss your overall health and make any necessary adjustments to your treatment plan.

Impaired Fasting Glucose: Taking Control of Your Health

Impaired fasting glucose is a warning sign, but it's also an opportunity. By understanding what IFG is, its causes, and its potential consequences, you can take proactive steps to manage your health and reduce your risk of developing type 2 diabetes and other related health problems. Focus on healthy lifestyle choices, regular monitoring, and open communication with your healthcare provider. With dedication and the right approach, you can significantly improve your long-term health and well-being.


Here is an example of an HTML table containing further information regarding managing IFG:

Strategy Details Expected Outcome
Dietary Changes Prioritize fiber-rich foods, lean proteins, and healthy fats. Limit processed sugars and refined carbohydrates. Consult with a nutritionist for tailored advice. Improved blood glucose control, weight management, and reduced insulin resistance.
Regular Exercise Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Incorporate both aerobic and strength training exercises. Increased insulin sensitivity, weight loss, improved cardiovascular health, and enhanced mood.
Stress Reduction Practice stress-reducing activities like meditation, yoga, or deep breathing exercises. Ensure adequate sleep (7-8 hours per night). Lower cortisol levels, improved blood sugar control, enhanced sleep quality, and reduced risk of stress-related complications.
Weight Management If overweight or obese, aim for a gradual weight loss of 1-2 pounds per week through a combination of diet and exercise. Reduced insulin resistance, improved blood glucose control, lower blood pressure, and decreased risk of diabetes.
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 As many of you are aware, much of our information that we present deals with problems of the brain and spinal cord. These have been described as being parts of the central nervous system. However, there is another part of the nervous system called the peripheral nervous system that is basically made up of the peripheral nerves. Peripheral neuropathy is a term that describes an abnormality with peripheral nerves. This can cause loss of sensation, pain, or even loss of autonomic function. Here in America some 20 million people suffer from peripheral neuropathy. In fact more than half of the people with diabetes will develop prayerful neuropathy at some point in their lifetimes. We are at increased risk for peripheral neuropathy not only as a consequence of diabetes but also as we age. Pray for neuropathy can be caused by chemotherapy and fully 1/4 of all peripheral neuropathy patients do not have an identifiable cost. There aren't really any FDA approved treatments to actually treat purple neuropathy in terms of the underlying cause of the nerve damage. While we do have drugs that treat, pain for example, again we need to find a way of treating the fire, not just focusing on the smoke. Having said that, there is an exciting new development in this field using drugs that are already available and are called muscarinic antagonists. Basically, they block the transmission of acetylcholine. In today's podcast, we are going to explore deeply, the mechanisms whereby this approach, using these muscarinic antagonists seems to be incredibly effective in growing new nerve fibers as well as increasing metabolism in the nerve itself leading to improvement ultimately in the manifestation of peripheral neuropathy. === 0:00 Intro 5:35 The Scope of the Problem 8:09 Diabetic Neuropathy 11:49 Neuropathy Following Chemotherapy 14:21 Viral Infections: HIV Treatment & Covid 16:56 Why Mitochondria are Essential in This 19:44 Pharmaceutical Study of Neuropathy 24:57 Aldose reductase inhibitor 29:31 Why This Approach is Different 37:44 How Antimuscarinics Work 48:10 Metrics for Getting FDA Approval 58:42 Funding the Research 1:01:53 Conclusion ==== Nigel A. Calcutt, Ph.D. ook both his B.Sc. in Zoology and Ph.D. Physiology and Pharmacology at Nottingham University, England. Following post-doctoral research in the Department of Pharmacology at St. Bartholomew’s Hospital, London and in the Department of Anesthesiology at the University of California San Diego, he was appointed to the faculty of the Department of Pathology at UC San Diego in 1993. Dr. Calcutt first began studying nerve damage caused by diabetes as an undergraduate, with a largely unsuccessful but nevertheless entertaining and informative attempt to normal blood sugar level after eating 2 hours generate diabetic chickens in the laboratory of the esteemed ornithologist Professor blood sugar 154 after eating David Tomlinson. Undeterred by the pitiful paucity of pre-diabetic poultry, he has continued to investigate mechanisms of diabetic neuropathy and neuropathic pain throughout his academic career, with a particular interest in translational studies. Dr. Calcutt is also a co-founder of the biotechnology company WinSanTor Inc. and the non-profit organization Diabetes Research Connection. Paul Fernyhough PhD received his PhD in biochemistry from the department of Biochemistry at University of Sheffield. He then carried out postdoctoral research at Colorado State University, Kings College London and as a Wellcome Trust Postdoctoral Fellow at St Bartholomew’s Medical College. He subsequently worked as a tenured lecturer in the School of Biological Sciences at the University of Manchester. Dr. Fernyhough moved to Winnipeg in 2004 and set up a neuroscience research group at St Boniface Hospital Albrechtsen Research Centre and holds a tenured professorship blood sugar vitamin in the Department of Pharmacology & Therapeutics at University of Manitoba. Dr. Fernyhough’s research interest is in the cell biology underlying neurodegenerative disorders of the peripheral nervous system with a focus on the impact of diabetes. A biotech start-up, WinSanTor Inc, has been established and is directing phase 2 clinical trials in diabetic neuropathy and chemotherapy-induced peripheral neuropathy. ___________________________ Instagram: Website: Subscribe to our channel:
Exciting Developments in the Treatment of Peripheral Neuropathy | Dr. Fernyhough & Dr. Calcutt
Exciting Developments In The Treatment Of Peripheral Neuropathy | Dr. Fernyhough & Dr. Calcutt [c6f411]